PTHRP-DERIVED MODULATORS OF SMOOTH MUSCLE PROLIFERATION

摘要

The present invention relates to the use of mutants of parathyroid hormone- related protein, to treat disorders associated with smooth muscle cells, and to inhibit the cellular activation and proliferation thereof. The method can be employed in diverse tissues to effect therapeutic and prophylactic relief for disorders and diseases manifested by activation of smooth muscle that ca n lead to excessive smooth muscle proliferation. For example, where employed i n the vasculature, the inventive method can be used to treat restenosis following angioplasty.