DERIVATIVES OF GLYCINERGIC R(+)-2-AMINO-3-HYDROXYPROPANOIC ACID

摘要

The invention relates to the use of derivatives of R(+)-2-amino-3- hydroxypropanoic acid which is substituted on the azote by a group: (C1- C6)alkyl, (C3-C6)alkenyl, 3-oxo(C5-C6)alkyl, 3-oxo(C4-C6)alken-2-yl, phenyl( C1- C6)alkyl, phenyl(C2-C6)alkenyl, gem-diphenyl(C1-C6)alkyl, gem-diphenyl(C2- C6)alkenyl, (C1-C6)alkanoyl, optionally N-substituted alanyl, optionally N,N '- disubstituted lysinoyl, phenyl(C1-C6)alkylidene or gem-diphenyl(C1- C6)alkylidene, and the pharmaceutically-acceptable salts thereof for the preparation of medicaments that are intended for the treatment of diseases o f the CNS due to reduced glycinergic transmission, such as for the treatment o f autism, schizophrenia and Alzheimer's disease.