摘要 |
Provided are novel compounds exhibiting excellent inhibitory activities against AMPA receptor and/or kainate receptor, i.e., compounds of the general formula (I), salts thereof, or hydrates of both wherein A, A and A are each independently C3-8 cycloalkyl, C3-8 cycloalkenyl, a 5- to 14-membered nonoaromatic heterocyclic group, a C6-14 aromatic carbocyclic group, or a 5- to 14-membered aromatic heterocyclic group, any of which may be substituted; Q is O, S, or NH; Z is C or N; X, X and X are each independently a single bond, optionally substituted C1-6 alkylene, optionally substituted C2-6 alkenylene, optionally substituted C2-6 alkynylene, -NH-, -O-, -NHCO-, -CONH-, -SO0-2-, or the like; R and R are each independently hydrogen or optionally substituted C1-6 alkyl, or alternatively R and R may be united in such a way that CR-ZR forms C=C; and R is hydrogen, optionally substituted C1-6 alkyl, or the like, or alternatively R may unite with any atom on the ring A or A to form together with the atom an optionally substituted C5-8 carbocycle or an optionally substituted 5to8 membered heterocycle. |