发明名称 |
(Hydroxyethyl)ureas as inhibitors of alzheimer's beta-amyloid production |
摘要 |
Novel (hydroxyethyl)ureas are described. These compounds are effective inhibitors of certain aspartyl proteases, notably secretases involved in the enzymatic cleavage of amyloid precursor protein (APP) to yield amyloid-beta peptide. Methods are provided for administering the novel compounds to treat beta-amyloid-associated diseases, notably Alzheimer's disease.
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申请公布号 |
US6696488(B2) |
申请公布日期 |
2004.02.24 |
申请号 |
US20010927913 |
申请日期 |
2001.08.10 |
申请人 |
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. |
发明人 |
WOLFE MICHAEL S.;SELKOE DENNIS J. |
分类号 |
A61K31/17;A61K31/223;A61K31/47;C07C275/24;(IPC1-7):A61K31/27 |
主分类号 |
A61K31/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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