发明名称 |
Preservative free ophthalmic oxazolidinone antibiotic drug delivery systems |
摘要 |
There is provided a pharmaceutical preservative free composition suitable for topical administration to an eye, the composition comprising (a) an oxazolidinone antimicrobial drug, for example linezolid, in a therapeutically or prophylactically effective drug concentration that is above the practical limit of solubility of the drug in a substantially isotonic aqueous solution at a physiologically compatible pH, and (b) a pharmaceutically acceptable cyclodextrin compound in a concentration sufficient to maintain the drug in solution at such a drug concentration. The composition is particularly useful for the treatment and/or prevention of eye infections due to gram positive bacteria.
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申请公布号 |
US6696426(B2) |
申请公布日期 |
2004.02.24 |
申请号 |
US20020080810 |
申请日期 |
2002.02.22 |
申请人 |
PHARMACIA CORPORATION |
发明人 |
SINGH SATISH K.;ADAMS LISA A.;BANDYOPADHYAY PARAMITA;HASAN SYED;HAWLEY LESLIE C.;SIMS SANDRA M. |
分类号 |
A61K9/00;A61K31/4439;A61K31/444;A61K31/496;A61K31/497;A61K31/5377;A61K47/12;A61K47/26;A61K47/40;A61K47/48;(IPC1-7):A61K31/715;A61K31/535 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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