发明名称 |
Antibodies for recognition of alk protein tyrosine/kinase receptor |
摘要 |
The present invention is based on the identification and sequence determination of a novel gene, ALK, which is fused to the gene encoding nucleophosmin (NPM) in translocations present in t(2;5) lymphoma cells. Based on homologies to other proteins, the amino acid sequence of the polypeptide encoded by the ALK (Anaplastic Lymphoma Kinase) gene is a membrane-spanning protein tyrosine kinase (PTK)/receptor. Antibodies to the ALK PTK/receptor and methods utilizing such antibodies are described, as are methods of using the ALK gene to isolate ligands for the ALK PTK/receptor.
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申请公布号 |
US6696548(B2) |
申请公布日期 |
2004.02.24 |
申请号 |
US20010827949 |
申请日期 |
2001.04.09 |
申请人 |
ST. JUDE CHILDREN'S RESEARCH HOSPITAL |
发明人 |
MORRIS STEPHAN W.;LOOK A. THOMAS |
分类号 |
C07K14/47;C07K16/18;C07K16/30;C12N9/12;(IPC1-7):C07K16/00 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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