DNA molecule encoding a variant alpha2B-adrenoceptor protein, and uses thereof

摘要

This invention relates to a DNA sequence comprising a nucleotide sequence encoding a variant alpha2B-adrenoceptor protein and to the variant alpha2B-adrenoceptor protein as well as a method for screening a subject to determine if the subject is a carrier of a variant gene that encodes the variant alpha2B-adrenoceptor protein. Further this invention relates to a method for treating a mammal suffering from vascular contraction of coronary arteries, the method comprising the step of administering a selective alpha2B-adrenoceptor antagonist to the mammal and to transgenic animals comprising a human DNA molecule encoding human alpha2B-adrenoceptor protein or the variant alpha2B-adrenoceptor protein.