发明名称 |
PREPARATION OF MULTIWALL POLYMERIC MICROCAPSULES FROM HYDROPHILIC POLYMERS |
摘要 |
Two or more hydrophilic, water soluble polymers that are not soluble in each other at a particular concentration and temperature, but which have a positive spreading coefficient in solution, are used to for m multi-layered polymeric microspheres. The multi-layer microspheres produced by the method are distinguished by extremely uniform dimensioned polymer layers and actual incorporation of a substance to be delivered into the polymer layers. In the preferred embodime nt of the method, two polymers are dissolved in an aqueous solvent, the substance to be incorporated is dispersed or dissolved in the polymer solution, the mixture is suspended in an organic solvent or polymer/water mixture and stirred, and the solvent is slowly evaporated, creating microspheres with an inner core formed by one polymer and an outer layer formed by the second polymer.
|
申请公布号 |
CA2352802(C) |
申请公布日期 |
2004.02.24 |
申请号 |
CA19982352802 |
申请日期 |
1998.12.01 |
申请人 |
BROWN UNIVERSITY RESEARCH FOUNDATION |
发明人 |
MATHIOWITZ, EDITH;JACOB, JULES S.;PEKAREK, KATHLEEN;CHICKERING, DONALD E., III |
分类号 |
C12N15/09;A61K9/50;A61K47/32;A61K47/34;A61K47/36;B01J13/06;B01J13/08;B01J13/12;(IPC1-7):B01J13/12 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|