METHODS FOR MODULATION OF FUNCTION OF SERINE/THREONINE-PROTEIN KINASE WITH 5-AZAQUINOXALINE-BASE COMPOUNDS, METHOD FOR IDENTIFICATION OF COMPOUNDS MODULATING FUNCTION OF SERINE/THREONINE-PROTEIN KINASE, METHOD FOR PROPHYLAXIS OR TREATMENT OF BODY PATHOLOGICAL STATE, 5-AZAQUINOXALINE-BASE PHARMACEUTICAL COMPOSITION AND METHOD FOR ITS SYNTHESIS

摘要

FIELD: organic chemistry, biochemistry, medicinal chemistry, pharmacy. SUBSTANCE: invention relates to methods for modulation of function of serine/threonine-protein kinases with 5-azaquinoxaline-base compounds. Methods involve using cells expressing serine/threonine-protein kinase, such as RAF. Except for, invention describes methods for prophylaxis and treatment associated with disturbances in metabolism of serine/threonine-protein kinase in pathological states in body using compound defined in the invention. Invention relates also to 5- azaquinoxaline-base compounds and pharmaceutical compositions comprising these compounds. EFFECT: expanded assortment of agents regulating function of serine/threonine-protein kinase. 40 cl, 4 tbl, 7 ex