发明名称 |
EXPRESSION OF CORE-GLYCOSYLATED HCV ENVELOPE PROTEINS IN YEAST |
摘要 |
The present invention relates to the general field of recombinant protein expression, purification of recombinant proteins, diagnosis of HCV infection, prophylactic treatment against HCV infection and to the prognosing/monitoring of the clinical efficiency of treatment of an individual with chronic hepatitis, or the prognosing/ monitoring of the natural disease. In particular, the present invention relates to the use of yeast, i.e. Hansenula or Saccharomyces glycosylation minus strains, for the efficient expression of HCV envelope proteins that are core-glycosylated, purification methods for these proteins, and the use in various applications, such as the use in diagnosis, prophylaxis or therapy of HCV envelope proteins purified according to the present invention. |
申请公布号 |
WO02086100(A3) |
申请公布日期 |
2004.02.19 |
申请号 |
WO2002BE00063 |
申请日期 |
2002.04.24 |
申请人 |
INNOGENETICS N.V.;BOSMAN, ALFONS;DEPLA, ERIK;DESCHAMPS, GEERT;SABLON, ERWIN;SAMSON, ISABELLE;VAN BROEKHOVEN, ANNIE;HAELEWYN, JOOST |
发明人 |
BOSMAN, ALFONS;DEPLA, ERIK;DESCHAMPS, GEERT;SABLON, ERWIN;SAMSON, ISABELLE;VAN BROEKHOVEN, ANNIE;HAELEWYN, JOOST |
分类号 |
G01N33/53;A61K38/00;A61K39/00;A61K39/29;A61P31/14;C07K;C07K14/18;C12N;C12N1/16;C12N1/19;C12N7/01;C12N7/04;C12N15/09;C12P21/02;G01N33/543;G01N33/576 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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