发明名称 |
SYNTHESIS OF EPOTHILONES AND RELATES ANALOGS |
摘要 |
The present invention relates to methods for use in producing epothilones and analogs and derivatives thereof. A general method according to the present invention broadly comprises performing an aldol condensation of a first compound with a second compund thereby to form a third compound selected from the formulas (I) and (II) and stereoisomers thereof, and performing a macrolactonization of the third compound. The present invention also provides chemical compounds, and methods for producing such chemical compounds, that are useful in producing epothilones and analogs and derivatives thereof. |
申请公布号 |
WO0230356(A3) |
申请公布日期 |
2004.02.19 |
申请号 |
WO2001US32225 |
申请日期 |
2001.10.15 |
申请人 |
THE UNIVERSITY OF MISSISSIPI |
发明人 |
AVERY, MITCHELL, A. |
分类号 |
A61K31/335;A61K31/427;A61P35/00;C07B51/00;C07B53/00;C07C17/093;C07C17/16;C07C45/29;C07C45/30;C07C45/41;C07C47/263;C07C47/277;C07C51/06;C07C51/353;C07C59/215;C07C59/76;C07D275/06;C07D277/24;C07D277/30;C07D313/00;C07D417/06;C07D493/04;C07F7/18 |
主分类号 |
A61K31/335 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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