摘要 |
Disclosed are thrombin peptide derivatives comprising a polypeptide having t he amino acid sequence SEQ ID NO. 2: Arg-Gly-Asp-Ala-Xaa-Gly-Asp-Ser-Gly-Gly-Pr o- Phe-Val, or a C-terminal truncated fragment of the polypeptide having at lea st six amino acids. Xaa is alanine, glycine, serine, or an S-protected cysteine . Zero, one, two, or three amino acids in the polypeptide or polypeptide fragment differ from the corresponding position of SEQ ID NO. 2. Also disclosed are methods of treating a subject in need of treatment with a thrombin receptor agonist. The methods comprise the step of administering an effective amount of the thrombin peptide derivative described above.
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