发明名称 THROMBIN PEPTIDE DERIVATIVES
摘要 Disclosed are thrombin peptide derivatives comprising a polypeptide having t he amino acid sequence SEQ ID NO. 2: Arg-Gly-Asp-Ala-Xaa-Gly-Asp-Ser-Gly-Gly-Pr o- Phe-Val, or a C-terminal truncated fragment of the polypeptide having at lea st six amino acids. Xaa is alanine, glycine, serine, or an S-protected cysteine . Zero, one, two, or three amino acids in the polypeptide or polypeptide fragment differ from the corresponding position of SEQ ID NO. 2. Also disclosed are methods of treating a subject in need of treatment with a thrombin receptor agonist. The methods comprise the step of administering an effective amount of the thrombin peptide derivative described above.
申请公布号 CA2491052(A1) 申请公布日期 2004.02.19
申请号 CA20032491052 申请日期 2003.07.01
申请人 THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 发明人 CARNEY, DARRELL H.
分类号 A61K38/00;A61K38/48;C07K;C12N9/74;(IPC1-7):C12N9/74 主分类号 A61K38/00
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