PRODUCTION OF alpha-KETO BUTYRATE

摘要

A process of obtaining alpha-keto butyrate by bioconversion is disclosed. The molecule is accumulated in the medium and is apt to subsequent processing to food ingredients, such as top-note flavors. A suitable strain is a natural ilv-3 mutant Neurospora crassa strain, which is capable of accumulating alpha-keto butyrate in the fermentation medium: By adjusting specific medium parameters, up to 8 g/l medium of alpha-keto butyrate was accumulated.