New heteroar(alkan)oyl-substituted phenyl-beta-alaninamide derivatives, useful as broad-spectrum antibacterial agents in human or veterinary medicine

摘要

N-(Heteroaroyl or heteroaralkanoyl)-phenyl-beta-alanine (2,5-dioxo-pyrrolidinocarbonyl)-alkylamides (I) are new. Phenyl-beta-alaninamide derivatives of formula (I) are new; R1 = heteroaryl (optionally substituted (os) by 1-3 groups R11); R11 = halo, alkyl, NO2, NH2, CF3, aryl, heteroaryl, OH, alkoxy, COOH, alkoxycarbonyl, CONH2 or alkylaminocarbonyl; R2 = H or Me R3, R4 = H or 1-3C alkyl; R5 = halo, CF3, OCF3, NO2, NH2, alkylamino, OH, alkyl, alkoxy, COOH, alkoxycarbonyl, CONH2, alkylaminocarbonyl, aryl or heteroaryl; or two groups R5 together complete a cycloalkyl or heterocyclyl ring (os by 1 or 2 groups R51); R51 = halo, NO2, NH2, CF3, OH, alkyl or alkoxy; R6 = alkyl, cycloalkyl or heterocyclyl (all os by 1 or 2 groups R61); R61 = halo, NO2, NH2, CF3, OH, alkyl or alkoxy; n = 0-3; m = 0-4. An Independent claim is also included for the preparation of (I).