Process for the preparation of alpha-aminosubstituted carboxylic acid amides

摘要

The invention relates to a process for the preparation of alpha-aminosubstituted carboxylic acid amide compounds and/or their salts comprising reacting a carboxylic acid amide of a primary amine with a nitrosylating agent in the presence of a base followed by hydrolysis to give a hydroxy imino derivative followed by hydrogenation and if necessary converting a base or acid of the alpha-aminosubstituted carboxylic acid amide into one of its salts.