A CHIMERIC REVERSE TRANSCRIPTASE AND METHODS FOR IDENTIFYING TELOMERASE INHIBITORS

摘要

The present invention provides nucleic acid molecules encoding a chimeric molecule, HIV-RT/hTERT, is based on HIV-1 Reverse Transcriptase (HIV-RT) and human telomerase reverse transcriptase (hTERT) catalytic site. HIV-RT/hTERT polypeptides and assays for screening compounds that bind to HIV-RT/hTERT and/or inhibit the reverse transcriptase activity of hTERT are also disclosed.