发明名称 |
PEPTIDES AS SOLUBILIZING EXCIPIENTS FOR TRANSFORMING GROWTH FACTOR SS PROTEINS |
摘要 |
The present invention relates to compositions comprising excipients or solubilizing agents for proteins. The invention relates to the discovery tha t a peptide derived from the N-terminus extension of the T266 isoform of rhBMP 2 has properties that enhance the solubility of proteins. The invention also relates to methods of resolubilizing a protein that has precipitated, by contacting the protein with a peptide comprised of the 17 amino acid extensi on of the T266 isoform of rhBMP-2. The invention also relates to methods of increasing the solubility of a protein by contacting the protein with a peptide comprised of the 17 amino acid extension of the T266 isoform of rhBM P- 2.
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申请公布号 |
CA2495222(A1) |
申请公布日期 |
2004.02.19 |
申请号 |
CA20032495222 |
申请日期 |
2003.08.12 |
申请人 |
WYETH |
发明人 |
PEREZ-RAMIREZ, BERNARDO;NICHOLS, PILARIN E. L. |
分类号 |
A61K38/07;A61K38/18;C07K7/08;C07K14/51;(IPC1-7):A61K38/07;C07K5/00;C07K7/00;A61K38/08;A61K38/10;C07K14/495 |
主分类号 |
A61K38/07 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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