1,6-FUSED URACIL DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS

摘要

This invention provides compounds defined by Formula (I) or a pharmaceutically acceptable salt thereof, wherein R<1>, Q, Y<6> Y<8>, R<2>, R<4>, and R<7> are as defined in the specification. The invention also provides pharmaceutical compositions comprising a compound of Formula (I) and the use of the compounds of Formula (I) for manufactures of medicaments useful for the treatment of rheumatoid arthritis (MMP-13 inhibitors).