Mutant p53 (delta126-132) protein and uses thereof

摘要

A p53 cDNA with a 21 nucleotide base deletion that codes for a seven amino acid deleted p53 protein was disclosed herein. The mutant p53 exhibits high cellular retention and is capable of rendering tumor cells sensitive to apoptotic inducing agents such as gamma-irradiation or chemotherapeutic agents. The mutant p53 protein can be delivered separately or in combination with apoptotic inducing agents via aerosol liposome/transfection/infection methods to treat cellular proliferative diseases and disorders in humans and animals.