Endovascular implant having an active coating

摘要

Endovascular implant with a coating containing a rexinoid receptor (RXR) agonist, or a combination of a peroxisome proliferator activated receptor (PPAR) agonist and a RXR agonist, or a PPARalpha and/or PPARdelta agonist, is new. ACTIVITY : Vasotropic. Tests involving implantation into the cardiovascular system of pigs showed that the coating reduced neointimal proliferation (no specific data given). MECHANISM OF ACTION : Rexinoid receptor (RXR) agonist; Peroxisome proliferator activated receptor (PPAR) agonist.