| 摘要 |
A solid support bound polynucleotide, preferably a 3'-O- or 5'-O-substituted polynucleotide, is disclosed. The polynucleotides are of formula: wherein Q is a substantially pure polynucleotide, each X is O or S; Y is an inert spacer group; R represents the solid support. Also disclosed is a method of isolating a target biomolecule, preferably a protein or a polynucleotide, from a mixture.
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