发明名称 |
Antisense modulation of sphingosine-1-phosphate lyase expression |
摘要 |
Antisense compounds, compositions and methods are provided for modulating the expression of sphingosine-1-phosphate lyase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding sphingosine-1-phosphate lyase. Methods of using these compounds for modulation of sphingosine-1-phosphate lyase expression and for treatment of diseases associated with expression of sphingosine-1-phosphate lyase are provided.
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申请公布号 |
US6692960(B2) |
申请公布日期 |
2004.02.17 |
申请号 |
US20010967669 |
申请日期 |
2001.09.28 |
申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
BENNETT C. FRANK;FREIER SUSAN M. |
分类号 |
A61K38/00;C12N5/02;C12N15/113;(IPC1-7):C07H21/04;C12Q1/68;C12N15/85;C12N15/86;C12P19/34 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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