发明名称 |
Pulmonary delivery of active agents |
摘要 |
The present invention provides methods for administering an active agent to an animal in need of the agent by the pulmonary route. This method comprises administering via the pulmonary route, a composition comprising (a) an active agent and (b)(i) an acylated amino acid, (ii) a sulfonated amino acid, or (iii) a combination of (i) and (ii). Administration of the compositions of the present invention provide improved pulmonary delivery and greater bioavailability of the active agent than administration of the active agent alone. As a result, lesser amounts of the active agent may be administered to obtain a desired result when contained in the composition of the present invention than when administered alone.
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申请公布号 |
US6693073(B2) |
申请公布日期 |
2004.02.17 |
申请号 |
US20020172582 |
申请日期 |
2002.06.14 |
申请人 |
EMISPHERE TECHNOLOGIES, INC. |
发明人 |
MILSTEIN SAM J.;SMART JOHN E.;SARUBBI DONALD J.;LEIPOLD MONICA;FLANDERS ELIZABETH;O'TOOLE DORIS;LEONE-BAY ANDREA;GSCHNEIDNER DAVID |
分类号 |
A61K31/16;A61K31/727;A61K38/12;A61K38/17;A61K38/18;A61K38/27;A61K38/28;A61K38/29;A61K38/30;A61K47/18;C07C235/64;(IPC1-7):A61K38/28;A61K38/00;A61K31/195 |
主分类号 |
A61K31/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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