| 发明名称 |
Method to remove citrate and aluminum from proteins |
| 摘要 |
A method is provided for removing citrate, aluminum, and other multivalent ions and contaminants from proteins by adjusting the pH of a solution containing the protein to a pH from about 7 to about 10, and diafiltering the pH-adjusted solution against aqueous solutions which have a low level of ions.
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| 申请公布号 |
US6693173(B2) |
申请公布日期 |
2004.02.17 |
| 申请号 |
US20010805397 |
申请日期 |
2001.03.13 |
| 申请人 |
ALPHA THERAPEUTIC CORPORATION |
发明人 |
MAMIDI RAJA R.;REGIS LETICIA R.;MOJICA MAURO C.;ITO HIROKAZU;GOTO TAKASHI |
| 分类号 |
A61K38/00;A61M1/02;A61M1/34;A61M1/36;C07K1/34;C07K14/76;(IPC1-7):A61K35/14;A61K38/48;C07K16/00 |
主分类号 |
A61K38/00 |
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