发明名称 |
Inhibition of lung metastases by aerosol delivery of p53 gene and anti-cancer compounds |
摘要 |
The present invention provides a method of inhibiting growth of lung metastases in an individual comprising the steps of administering in a combination an aerosolized polyethylenimine-DNA complex and an aerosolized liposome-anticancer drug complex with both of the complexes delivered via aerosolization. Delivery of both the DNA and the anticancer drug via this method inhibits growth of lung metastases in the individual. Also provided is a method of inhibiting growth of lung metastases in an individual by the administration in combination via aerosolization of a polyethylenimine-p53 complex and a dilauroylphosphatidylcholine-9-nitrocamptothecin complex.
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申请公布号 |
US2004028616(A1) |
申请公布日期 |
2004.02.12 |
申请号 |
US20030366937 |
申请日期 |
2003.02.14 |
申请人 |
KNIGHT J. VERNON;GILBERT BRIAN;KOSHKINA NADEZHDA;WALDREP L. CLIFFORD;DENSMORE CHARLES L.;GAUTAM AJAY |
发明人 |
KNIGHT J. VERNON;GILBERT BRIAN;KOSHKINA NADEZHDA;WALDREP L. CLIFFORD;DENSMORE CHARLES L.;GAUTAM AJAY |
分类号 |
A61K9/127;A61K9/72;A61K31/00;A61K31/255;A61K31/282;A61K31/337;A61K31/4745;A61K31/475;A61K31/506;A61K31/513;A61K31/519;A61K31/675;A61K31/704;A61K31/7048;A61K31/7088;A61K31/7105;A61K31/711;A61K38/20;A61K38/21;A61K45/00;A61K45/06;A61K47/24;A61K47/34;A61K47/48;A61K48/00;A61P11/00;A61P35/00;A61P35/04;(IPC1-7):A61K48/00;A61L9/04 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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