P53-associated Parkin-like cytoplasmic protein, and related compositions and methods

摘要

This invention provides an isolated p53-associated Parkin-like cytoplasmic protein ("Parc") having use, for example, as an anti-cancer target. This invention also provides related recombinant proteins and nucleic acids such as vectors and anti-sense molecules. Further provided are anti-Parc antibodies, protein and antibody production methods, Parc-based screening assays, methods and compositions for decreasing Parc expression and treating subjects, diagnostic methods, and related kits.