发明名称 |
Process for preparation of 2-amino-6 (alkyl) amino-4,5,6,7-tetrahydrobenzothiazoles |
摘要 |
A new process to obtain pramipexole and related products is described. The process involves the reaction of new compounds of formula (6), wherein R is hydrogen or acyl group, R3 and R4 are either the same and each of them represents an alkoxy group of 1-4 carbons or they together form a C2-C5 alkylenedioxy group or an oxo-group, with an alkylamine in the presence of a reducing agent or a hydrogen gas with hydrogenation catalyst. A process to obtain new compounds of formula (6) is also described.
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申请公布号 |
US2004029936(A1) |
申请公布日期 |
2004.02.12 |
申请号 |
US20030380758 |
申请日期 |
2003.08.07 |
申请人 |
POSPISILIK KAREL;HOORN HANS JAN;PETERS THEODORUS HENDRICUS ANTONIUS;LEMMENS JACOBUS MARIA |
发明人 |
POSPISILIK KAREL;HOORN HANS JAN;PETERS THEODORUS HENDRICUS ANTONIUS;LEMMENS JACOBUS MARIA |
分类号 |
C07D277/82;(IPC1-7):C07D277/82;A61K31/428 |
主分类号 |
C07D277/82 |
代理机构 |
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