MONOCLONAL ANTIBODY TO MICROTUBULAR ASSOCIATED PROTEIN TAU

摘要

PROBLEM TO BE SOLVED: To obtain a monoclonal antibody forming an immune complex with a phosphorylated epitope of an antigen belonging to a human abnormally-phosphorylated tau protein.

SOLUTION: This monoclonal antibody forms the immune complex with the phosphorylated epitope which exists in the human abnormally-phosphorylated tau protein obtained from a brain homogenate separated from the cerebral cortex of a patient who has Alzheimer's disease or died due to the Alzheimer's disease, but not exists in a normal human tau protein.

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