| 摘要 |
Valved prostheses are described with crosslinked leaflets (102, 104, 106). A t least one of the leaflets has a shape corresponding to a contoured surface. The leaflets are individually attached to the prostheses. Furthermore, in so me embodiments, the leaflets do not comprise native leaflet tissue. Methods for forming tissue heart valve prostheses can comprise assembling a plurality of leaflets configured to open and close the valve in response to pressure differentials. Each of the plurality of leaflets is preformed individually when at least partially crosslinked in contact with a contoured surface. The individual crosslinked leaflets can be selected and matched for assembly int o a valve. In general, the tissue, when it is crosslinked, has a size and shap e approximately the size of a single human heart valve leaflet.
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