发明名称 AFFINITY LABELING OF SERINE PROTEASES FOR SIMULTANEOUS DETECTION OF MULTIPLE SERINE PROTEASE ACTIVITY LEVELS
摘要 The invention prvides assay methods and reagents useful for evaluating the level of enzyme activities within living cells. Enzyme activity levels within living cells, such as Serine proteases, can be key determinates in assessing; 1) the presence of tumor (cancer) cells, 2) the predictive efficacy of a chemotherapeutic treatment a regime using a particular therapeutic agent or process, 4) the probability of graft rejection or acceptance, and 5) the disease state status of a cell. The identification of the up or down regulation relationships of serine proteases within living cell systems, provides a rapid, yet finely tuned mechanism for predicting the current and future physiological state of these cell populations.
申请公布号 WO03060466(A3) 申请公布日期 2004.02.12
申请号 WO2002US40689 申请日期 2002.12.19
申请人 IMMUNOCHEMISTRY TECHNOLOGIES, LLC;PHELPS, DAVID, J.;JOHNSON, GARY, L.;LEE, BRIAN, W.;DARZYNKIEWICZ, ZBIGNIEW;GRABAREK, JERZY 发明人 PHELPS, DAVID, J.;JOHNSON, GARY, L.;LEE, BRIAN, W.;DARZYNKIEWICZ, ZBIGNIEW;GRABAREK, JERZY
分类号 G01N33/50;G01N33/573 主分类号 G01N33/50
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