TRANSGENIC MICE CONTAINING TARGETED GENE DISRUPTIONS

摘要

The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in a CHD2-like gene, a TDCDF1 gene, a TR2 gene, an E3-like gene, a CSPI gene, and an Abcd2 gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease condition.