发明名称 |
ANTISENSE MODULATION OF PROTEIN EXPRESSION |
摘要 |
Antisense compounds, compositions and methods are provided for modulating the expression of H-Ras, WNT-7B, acetylglucosaminyltransferase, voltage-gated K chananel, IL-8, ion transport, Map3K8 and Thymidine kinase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids ancoding H-Ras, WNT-78, acetylglucosaminyltransferase, voltage-gated K channel, IL-8, ion transport, Map3K8 and Thymidine kinase. Methods of using these compounds for modulation of H-Ras, WNT-7B, acetylglucosaminyltransferase, voltage-gated K channel, IL-8, ion transport, Map3K8 and Thymidine kinase expression and for treatment of diseases associated with expression of H-Ras, WNT-7B, acetylglucosaminyltransferase, voltage-gated K channel, IL-8, io n transport, Map3K8 and Thymidine kinase are provided. |
申请公布号 |
WO03070160(A3) |
申请公布日期 |
2004.02.12 |
申请号 |
WO2002US38188 |
申请日期 |
2002.11.27 |
申请人 |
CURAGEN CORPORATION;JU, JINGFANG;HUANG, CHUNLI;ZHONG, HAIHONG;SIMONS, JAN, FREDIK;TAILLON, BRUCE, E.;CHANT, JOHN, S.;PEYMAN, JOHN, A.;SMITHSON, GLENNDA;MILLET, ISABELLE |
发明人 |
JU, JINGFANG;HUANG, CHUNLI;ZHONG, HAIHONG;SIMONS, JAN, FREDIK;TAILLON, BRUCE, E.;CHANT, JOHN, S.;PEYMAN, JOHN, A.;SMITHSON, GLENNDA;MILLET, ISABELLE |
分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
代理机构 |
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