METHODS AND COMPOSITIONS FOR TREATING BENIGN GYNECOLOGICAL DISORDERS, CONTRACEPTION, AND HORMONE REPLACEMENT

摘要

A method and improvement of treating benign gynecological disorders is described. The method is also suitable for contraception and for hormone replacement therapy. In the method, treatment of a benign gynecological disorder with a composition comprised of a gonadotropin releasing hormone (GnRH) compound and an estrogenic compound, and optionally, an androgenic compound. The composition may be formulated as a nasal spray comprised of a GnRH compound and an estrogenic compound in the form of a water-soluble complex with a water-soluble cyclodextrin. The present invention further relates to an improvement in a method of contraception, in treatment of benign gynecological disorders, and in hormone replacement by administering intranasally an estrogenic compound and an androgenic compound, and in some embodiments an optional progestin compound, in a once-daily bolus formulation comprised of the two or three steroids complexed with a cyclodextrin. An intranasal delivery system for administration of the formulation is also described.