发明名称 |
SPECTROSCOPIC UNWANTED SIGNAL FILTERS FOR DISCRIMINATION OF VULNERABLE PLAQUE AND METHOD THEREFOR |
摘要 |
<p>Spectral variation contributed from the absorbance of unwanted correlated signals, such as blood at variable pathlengths between an in vivo catheter optic probe and a coronary vessel wall is an obstacle in the detection of vulnerable plaque. Preprocessing methods are described to reduce the impact of blood upon the spectral signal, based on the principles of Orthogonal Subspace Projection (OSP) and Generalized Least Square (GLS). The multivariate discrimination models used on the processed spectral information reduce the number of independent factors that include contributions from blood. The disclosed chemometric processing including preprocessing methods provide for in vivo spectral detection of medical analytes within the human body and in particular within the coronary vessel wall.</p> |
申请公布号 |
WO2004012594(A1) |
申请公布日期 |
2004.02.12 |
申请号 |
WO2003US23624 |
申请日期 |
2003.07.29 |
申请人 |
INFRAREDX, INC.;MARSHIK-GEURTS, J., BARBARA;TAN, HUWEI |
发明人 |
MARSHIK-GEURTS, J., BARBARA;TAN, HUWEI |
分类号 |
G01N21/35;A61B5/00;A61B5/02;A61B5/145;A61B5/1455;A61B10/00;(IPC1-7):A61B5/00 |
主分类号 |
G01N21/35 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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