METHOD FOR MR/NMR IMAGING

摘要

The present invention features an MRI/NMR methodology or process for detecting exogenous amide protons in a region of interest of a body or sample via the water signal. Such methods and processes can be used for any of a number of purposes including determining and assessing the delivery and/or content of a molecular or cellular target(s), such as ligands, oligonucleotides, and RNA/DNA (including plasmids) tagged or labeled by an exogenous contrast agent sourcing such amide protons; detecting and assessing pH effects, more particularly the pH of the liquid pool (e.g., blood); and as a mechanism for MR/NMR signal enhancement (e.g., providing another mechanism for developing contrast between tissues, etc. of the region of interest.