METHODS AND REAGENTS RELATING TO INFLAMMATION AND APOPTOSIS

摘要

The present invention relates to, among other embodiments, protein complexes which include tumor necrosis factor alpha (TNF-.alpha.) and/or tumor necrosi s factor alpha receptor (TNFR). Preferably, the complexes comprise at least on e polypeptide selected from the group consisting of: NF-~B activating kinase (NAK), RasGAP3, TRCP1, and TRCP2. The present invention further provides assays of identifying a compound for modulating the stability and activity o f the complex. Also provided are methods of modulating apoptosis and inflammation, as well as treating TNF-.alpha. related diseases.