Real time monitoring of small particle dissolution by way of light scattering

摘要

A method for determining the percent of a solid material dissolved into a liquid medium is disclosed. The method comprises the steps of combining the solid material and the liquid medium; determining the initial solid concentration (i); determining the dynamic solid concentration (d) using a light scattering technique; and calculating the percent dissolved material according to the formula: [(i-d)/i]x100. Methods for determining dissolution rate and particle size using turbidity measurements are also disclosed.