MODULATION OF ANGIOGENESIS BY A-BETA PEPTIDES

摘要

The present invention provides methods and compositions for treating diseases and pathological conditions or processes mediated by undesired and/or uncontrolled angiongenesis (characterized as "angiogenic diseases") by increasing the in vivo concentration of the A beta peptide, or biologically active fragments or variants of the A beta peptide, within a patient suffering from such diseases, conditions, or processes. The present invention also concerns diagnostic methods and kits for detection and measurement of anti-angiogenic A beta peptide activity in biological fluids and tissues. Such diagnostic methods and kits can be utilized to screen compounds for potential therapeutic activity in the treatment of Alzheimer's disease.