COMPOSITIONS COMPRISING MIXTURES OF THERAPEUTIC PROTEINS AND METHODS OF PRODUCING THE SAME

摘要

Human cytokine mixtures produced by cytokine regulatory factor-overexpressing cells and methods of production are disclosed. The mixtures are prepared by culturing human cytokine-producing cells under conditions of cytokine regulatory factor overexpression, treating the cells to induce cytokine production, and isolating the mixtures of cytokines produced by the cells. Preferred compositions, for use in treating viral infection or cancer, include a mixture of human interferon gamma and either human interferon alpha or human interferon beta , in a mole ratio of between 1:1 to 1:100 interferon gamma to interferon alpha or human interferon beta .