| 摘要 |
Active ingredients capable of stimulating directly or indirectly the expression of type 2 or type 3 beta defensins in humans, but which do not stimulate either inflammatory, irritation or intolerance reactions, or the synthesis of proinflammatory molecules, such as MIP 3 alpha, IL8, IL1 or other interleukins, histamine, tryptase, substance P or leucotrines or prostaglandins. More preferably the active ingredient is chosen from a plant or extract thereof, such as artemisia, erigeron, elderberry, rupturewort, pineapple, peppermint, areca, cocoa, quinoa, arnica, boldo, sarsparilla, walnut, hibiscus, pumpkin, sunflower, peony, St John's wort, horse chestnut, or from jasmonic acid, vitamin A, alpha-MSH, isoluencine esters or organic or mineral calcium. Also claimed are assay and methods for screening for such compounds, as well as cosmetic and pharmaceutical compounds containing such active ingredients. |
