发明名称 |
Borrelia burgdorferi polypeptides and uses thereof |
摘要 |
The present invention provides novel polypeptides which are substantially free of a B. burgdorferi spirochete or fragments thereof and which are thus useful in compositions and methods for the treatment and prevention of B. burgdorferi infection and Lyme disease. In one preferred embodiment, this invention provides modified OspA polypeptides and pharmaceutically effective compositions and methods comprising those polypeptides. Preferred modified OspA polypeptides are characterized by modifications which diminish and/or ablate their ability to bind the human MHC allele HLA-DRB1*0401.
|
申请公布号 |
US6689364(B2) |
申请公布日期 |
2004.02.10 |
申请号 |
US20010812635 |
申请日期 |
2001.03.20 |
申请人 |
TUFTS UNIVERSITY |
发明人 |
HUBER BRIGITTE T.;WILLETT THERESA;MEYER ABBIE;GROSS DAWN |
分类号 |
A61K39/00;C07K14/20;(IPC1-7):A61K39/00;A61K49/00;A61K39/02;A61K39/38 |
主分类号 |
A61K39/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|