发明名称 Halogen-modified silicon, surfaces
摘要 Chemically-modified surfaces on unoxidized, bromine- or iodine-terminated carbon, silicon, and germanium substrates are disclosed. Visible light mediates the reaction of protected omega-modified, alpha-unsaturated aminoalkenes (preferred) with bromine- or iodine-terminated carbon, silicon, or germanium surfaces. Removal of the protecting group yields an aminoalkane-modified silicon surface. These amino groups can be coupled to terminal-modified oligonucleotides using a bifunctional crosslinker, thereby permitting the preparation of modified surfaces and arrays. Methods for controlling the surface density of molecules attached to the substrate are also disclosed.
申请公布号 US6689858(B2) 申请公布日期 2004.02.10
申请号 US20010770885 申请日期 2001.01.26
申请人 WISCONSIN ALUMNI RESEARCH FOUNDATION 发明人 HAMERS ROBERT J.;CAI WEI;SMITH LLOYD M.;STROTHER TODD C.
分类号 G01N33/53;B05D1/18;C12M1/00;C12N15/09;C12Q1/68;G01N37/00;H01L51/00;H01L51/30;(IPC1-7):C08G77/00;C07H21/04 主分类号 G01N33/53
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