发明名称 |
STRUCTURAL CAROTENOID ANALOGS FOR THE INHIBITION AND AMELIORATION OF DISEASE |
摘要 |
A method for inhibiting and/or ameliorating the occurrence of diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals in a subject whereby a subject is administered a carotenoid structural analog, either alone or in combination with another carotenoid analog, or co-antioxidant formulation. The analog or analog combination is administered such that the subject's risk of experiencing diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals may be thereby reduced. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of ischemia-reperfusion injury. The analog or analog combinatio n may be administered to a subject for the inhibition and/or amelioration of liver disease. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of cancer. The analog or anal og combination may be administered to a subject for the inhibition and/or amelioration of cardiac arrhythmia and/or sudden cardiac death. The analog o r analog combination may be administered to a subject for the inhibition and/o r amelioration of any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In one embodiment, a water-soluble and/or water-dispersible astaxanthin analog is particularly effective. This invention further includes pharmaceutical compositions comprising structural carotenoid analogs either alone or in combination.
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申请公布号 |
CA2495167(A1) |
申请公布日期 |
2004.02.05 |
申请号 |
CA20032495167 |
申请日期 |
2003.07.29 |
申请人 |
HAWAII BIOTECH, INC. |
发明人 |
O'MALLEY, SEAN;WATUMULL, DAVID G.;HIX, LAURA M.;LOCKWOOD, SAMUEL FOURNIER;JACKSON, HENRY;NADOLSKI, GEOFF |
分类号 |
A01N27/00;A61K31/01;A61K31/015;A61K31/045;A61K31/07;A61K31/075;A61K31/12;A61K31/13;A61K31/185;A61K31/215;A61K31/225;A61K31/255;A61K31/325;A61K31/401;A61K31/404;A61K31/4172;A61K31/535;A61K31/537;A61K31/5377;A61K31/66;A61K31/6615;A61K31/665;A61K31/70;A61K31/7024;A61K31/704;A61K31/715;A61P1/16;A61P9/04;A61P9/06;A61P35/00;C07C403/24;C07D207/16;C07D233/60;C07D265/30;C07D307/58;C07F9/02;C07F9/117;C07H13/04;(IPC1-7):C07C403/24;A61K31/558;A61K31/661;A61K31/702 |
主分类号 |
A01N27/00 |
代理机构 |
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