发明名称 STABLE COMPOSITION COMPRISING TEZACITABINE
摘要 PROBLEM TO BE SOLVED: To obtain an aqueous composition comprising tezacitabine and having good storage stability. SOLUTION: This composition comprises (a) water, (b) the tezacitabine and (c) a buffer for maintaining the pH of the composition at about 7 or above. The buffer for adjusting the pH is selected from the group consisting of TRIS (2-amino-2-hydroxymethyl-1,3-propanediol), glycine, a glutamate and a phosphate. The composition has a pH 8-11, preferably 8.5-10.0. COPYRIGHT: (C)2004,JPO
申请公布号 JP2004035408(A) 申请公布日期 2004.02.05
申请号 JP20020107196 申请日期 2002.04.09
申请人 CHIRON CORP 发明人 JONES RICHARD;LI MICHAEL;TRAMMEL ANDY;HARRISON-BOWMAN CHRISTINE M;SHIRLEY KIMBERLY R
分类号 A61K9/08;A61K31/7068;A61K31/7072;A61K47/02;A61K47/04;A61K47/18;A61P35/02;(IPC1-7):A61K31/706 主分类号 A61K9/08
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