| 发明名称 |
Altered OspA of Borrelia burgdorferi |
| 摘要 |
Provided herein are OspA polypeptides from Lyme Disease-causing Borrelia having certain alteration(s). In one embodiment, the alteration(s) increase the conformational stability of the OspA polypeptide containing the alteration(s) while maintaining at least some of the antigenicity of the corresponding unaltered OspA polypeptide. In another embodiment, the altered OspA polypeptide has reduced cross-reactivity to hLFA-1, as compared to the corresponding unaltered OspA polypeptide. |
| 申请公布号 |
US2004023325(A1) |
申请公布日期 |
2004.02.05 |
| 申请号 |
US20030369339 |
申请日期 |
2003.02.18 |
| 申请人 |
RESEARCH FOUNDATION OF THE STATE UNIVERSITY OF NEW YORK;BROOKHAVEN SCIENCES ASSOCIATES, LLC;UNIVERSITY OF ROCHESTER |
发明人 |
LUFT BENJAMIN J.;DUNN JOHN J.;KOIDE SHOHEI;LAWSON CATHERINE L. |
| 分类号 |
A61K39/00;C07K14/20;C12N1/21;C12N15/31;(IPC1-7):C12P21/02;C07K14/195;C12N15/74 |
主分类号 |
A61K39/00 |
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