| 摘要 |
Topical compositions and methods including non-amphoteric derivatives of glutathione, for example, N-acyl-glutathiones, N-acyl-glutathione amides, and N-acyl-glutathione esters are disclosed for use in the treatment and prevention of cosmetic conditions and dermatological disorders, are disclosed. The non-amphoteric glutathione derivatives may have the structure of (I): R' -COCHNH (R<2>) H2CH2CONHCH(CH2SR<3>) CONHCH2 CO-R' wherein R' is independently selected from -OH, -NH2, -NHNH2, an alkoxyl group, an aralkoxyl group, and an aryloxyl group and R<2> and R<3> are each independently selected from a hydrogen atom or an acyl group, but if at least one R' is -OH, -NH2, or -NHNH2, then R<2> is an acyl group. |
