发明名称 |
KINASE INHIBITORS |
摘要 |
This invention provides phenyl-substituted pyrimidopyrimidines, dihydropyrimido-pyrimidines, pyridopyrimidines, naphthyridines,and pyridopyrazines of the general formula (I) that inhibit cyclin-dependent kinase and tyrosine kinase enzymes, methods and intermediate compounds for their synthesis,as well as pharmaceutical compositions and methods for their use in treating, inhibiting or preventing maladies associated with cell proliverative disorders, including angiogenesis, atherosclerosis, restenosis , and cancer.
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申请公布号 |
CA2493633(A1) |
申请公布日期 |
2004.02.05 |
申请号 |
CA20032493633 |
申请日期 |
2003.07.21 |
申请人 |
WARNER-LAMBERT COMPANY LLC |
发明人 |
HAMBY, JAMES MARINO;HOYER, DENTON WADE;DEUR, CHRISTOPHER JAMES;LIMBERAKIS, CHRIS;CONNOLLY, CLEO J. CHIVIKAS;SCHROEDER, MEL CONRAD;TAYLOR, CLARKE BENTLEY;REED, JESSICA ELIZABETH |
分类号 |
A61K31/519;A61P1/04;A61P9/00;A61P9/10;A61P11/00;A61P13/08;A61P13/12;A61P17/06;A61P19/02;A61P19/10;A61P25/00;A61P27/06;A61P29/00;A61P31/20;A61P31/22;A61P35/00;A61P37/06;A61P43/00;C07C65/21;C07D487/04;(IPC1-7):C07D487/04;A61K31/505 |
主分类号 |
A61K31/519 |
代理机构 |
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代理人 |
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地址 |
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