| 摘要 |
<P>PROBLEM TO BE SOLVED: To obtain a new drug suppressing constriction and intimal thickening of blood vessels by preventing penetration of vascular stem cells and useful for prophylaxis or treatment of various kinds of vascular lesions according thereto. <P>SOLUTION: An inhibitor of the penetration into the vascular walls of the vascular stem cells comprises a sulfonic acid azo dye and/or a phenanthridinium dye as an active ingredient. The inhibitor of the penetration into the vascular walls of the vascular stem cells has actions on remarkable inhibition of penetration of the vascular stem cells into the vascular walls and is useful for prophylaxis or treatment of vascular proliferating diseases such as embolization due to intimal thickening, boss forming and vascular rupture caused thereby, proliferative retinopathy caused by excessive neovascularization, vascular proliferative diseases of the inflammatory, metabolic, congenital character, etc., such as proliferation of solid tumor by exacerbation of congenital arteriovenous fistulas or nutritive neovascularization. <P>COPYRIGHT: (C)2004,JPO |
