NOVEL NUCLEIC ACID AND POLYPEPTIDE MOLECULES

摘要

The presetn invention provides for nucleic acid sequences that encoude novel mamalian intracellular signaling polypeptides, designated MURF1, MURF3, or MA-61. The invention also provies assay systems that may be used to detect and/or measure agents that bind the MURFI or MAFBXgene product. The present invention also provides for diagnostic and therapeutic mehtods based on the interacton between MURF1 or MAFBX and agenets that initiate signal transduction or inhibition of ubiqutination throgh binding to MURF1 or MA-61, inhibiting the mRNA expression of MURF1, MURF3, or MA-61, or inhibiting the MURF1, MURF3, or MAFBXpathway.