发明名称 |
INJECTABLE MULTIMODAL POLYMER DEPOT COMPOSITIONS AND USES THEREOF |
摘要 |
Injectable depot compositions are provided that include a polymer matrix having a plurality of bioerodible, biocompatible polymers wherein each polym er of the plurality of polymers has a specified weight average molecular weight ; and the polymer matrix has a broad molecular weight distribution of the plurality of polymers; a solvent having a miscibility in water of less than or equal to 7 wt.% at 25~C, in an amount effective to plasticize the polymer an d form a gel therewith; and a beneficial agent. The compositions are have substantially improved the shear thinning behavior and reduced injection force, rendering the compositions readily implanted beneath a patient's body surface by injection. The most preferred polymer matrix is made of poly (lactide-co-glycolide) copolymers, commonly referred to as PLGA. The most preferred solvents are derivatives of benzoic acid, such as benzylbenzoate.< /SDOAB> |
申请公布号 |
CA2494400(A1) |
申请公布日期 |
2004.02.05 |
申请号 |
CA20032494400 |
申请日期 |
2003.07.28 |
申请人 |
ALZA CORPORATION |
发明人 |
CHEN, GUOHUA;KLEINER, LOTHAR;HOUSTON, PAUL;WRIGHT, JEREMY |
分类号 |
A61K47/38;A61K9/00;A61K9/06;A61K9/10;A61K9/14;A61K9/20;A61K47/08;A61K47/10;A61K47/12;A61K47/14;A61K47/22;A61K47/24;A61K47/32;A61K47/34;A61K47/36;A61L31/00;(IPC1-7):A61K9/00 |
主分类号 |
A61K47/38 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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